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New small-molecule drug design strategies for fighting resistant influenza A

Identifieur interne : 000541 ( Main/Exploration ); précédent : 000540; suivant : 000542

New small-molecule drug design strategies for fighting resistant influenza A

Auteurs : Zuyuan Shen [République populaire de Chine] ; Kaiyan Lou [République populaire de Chine] ; Wei Wang [République populaire de Chine, États-Unis]

Source :

RBID : PMC:4629447

Abstract

Influenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main treatment strategies–vaccination and small molecule anti-influenza drugs are currently available. As an effective vaccine usually takes at least 6 months to develop, anti-influenza small molecule drugs are more effective for the first line of protection against the virus during an epidemic outbreak, especially in the early stage. Two major classes of anti-influenza drugs currently available are admantane-based M2 protein blockers (amantadine and rimantadine) and neuraminidase (NA) inhibitors (oseltamivir, zanamivir, and peramivir). However, the continuous evolvement of influenza A virus and the rapid emergence of resistance to current drugs, particularly to amantadine, rimantadine, and oseltamivir, have raised an urgent need for developing new anti-influenza drugs against resistant forms of influenza A virus. In this review, we first give a brief introduction of the molecular mechanisms behind resistance, and then discuss new strategies in small-molecule drug development to overcome influenza A virus resistance targeting mutant M2 proteins and neuraminidases, and other viral proteins not associated with current drugs.


Url:
DOI: 10.1016/j.apsb.2015.07.006
PubMed: 26579472
PubMed Central: 4629447


Affiliations:


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